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These effects, along with a earlier report exhibiting that a small-molecule ACKR3 agonist CCX771 exhibits anxiolytic-like actions in mice,two help the idea of focusing on ACKR3 as a novel strategy to modulate the opioid technique, which could open new therapeutic avenues for opioid-relevant Ailments.Tabernaemontana divaricata Conolidine can be an i